By Philippe Derreumaux
Alzheimer's illness is the commonest type of senile dementia, affecting greater than 24 million humans all over the world. it's characterized pathologically via abnormally excessive degrees of neurofibrillary tangles caused by the buildup of tau protein in lifeless and loss of life neurons, and by way of increased numbers of senile plaques within the cortex and hippocampus of the mind. the main component to senile plaques is a small protein of 39–43 amino acids referred to as amyloid-β (Aβ). so far, no remedy has been proven to sluggish the development of sporadic and familial Alzheimer's disease.
A huge physique of proof issues, although, to the early Aβ-formed oligomers because the fundamental poisonous species in Alzheimer's affliction. a strong process for constructing pharmaceutical remedies opposed to Alzheimer's is to clarify the pathways of oligomer formation and make certain the buildings of the poisonous aggregates.
This publication presents a wide ranging view throughout contemporary in vitro and in vivo experiences in addition to cutting-edge desktop simulations, designed to extend the readers' realizing of Aβ oligomerisation and fibril formation. whilst, the ebook delves into the pathogenesis of familial and sporadic Alzheimer's affliction on the atomic point of detail.
Written by means of best authors of their respective fields, this publication should be necessary to all scientists engaged on Alzheimer's disease.
Readership: normal public, PhD scholars, postdocs, in addition to all scientists operating within the following fields: Alzheimer's sickness, amyloids, neuroscience, oligomers, protofibrils, fibrils, toxicity, buildings, dynamics, kinetics, thermodynamics, all-atom and coarse grained simulations, biophysics, reminiscence, studying, transgenic mouse versions, steel ions, membrane, nanoparticles, computational chemistry, drug layout and bioinformatics.
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Extra info for Alzheimer's Disease: Insights into Low Molecular Weight and Cytotoxic Aggregates from In Vitro and Computer Experiments:Molecular Basis of Amyloid-Beta ... (Molecular Medicine and Medicinal Chemistry)
Alzheimer's Disease: Insights into Low Molecular Weight and Cytotoxic Aggregates from In Vitro and Computer Experiments:Molecular Basis of Amyloid-Beta ... (Molecular Medicine and Medicinal Chemistry) by Philippe Derreumaux